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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4

Fig. 8

The working model: Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4. Meox1 triggered adventitia Sca-1+ progenitor cell migration into neointimal and accelerated neointimal formation. SDF-1α induced by Meox1 in VSMC promoted Sca-1+ progenitor cell migration through activating CXCR4. CDC42 was involved in SDF-1α expression in VSMC and CXCR4 expression in Sca-1+ progenitor cells mediated by Meox1. I, neointima; M, media; A, adventitia

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Stem Cell Research & Therapy

ISSN: 1757-6512