Fig. 4
UC-MSCs combined with FMD improved glucose homeostasis as UC-MSC infusion. a Experimental scheme to determine effects of the periodic FMD and UC-MSCs on DIO mice. Each FMD cycle entails 4 days FMD and 7 days of refeeding (RF), which forms 11 days per cycle for 7 cycles. During refeeding, mice received a HFD identical to that given prior to the FMD. The control and UC-MSC groups have access to ad libitum feeding. b Fasting blood glucose levels were monitored after fasting 6 h at sacrificed. c, d Glucose tolerance was assessed by IPGTT. AUC above baseline was calculated as an index of glucose tolerance. e–g ELISA analyzed HbA1c, Hb, and serum insulin. The data are expressed as mean values ± SD. n = 6 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001