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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10

Fig. 2

Effect of IL-10 on H295R cells. a Concentration of IL-10 secreted by BM-hMSC presented as the mean ± SD (n=4). Relative gene expression of b CYP17A1, c CYP11A1, and d DENND1A after IL-10 treatment. e Testosterone secretion and f androstenedione secretion by H295R cells after IL-10 treatment. Relative gene expression of inflammatory markers g IL-6 (IL6), h TNF-α (TNFA), and i IL-1β (IL1B) after IL-10 treatment. *p<0.05, **p<0.005; NS, not significant. b–i All graphs are presented as the mean ± SD (n=3). Statistical significances were determined by 2-way ANOVA or nonparametric T-test (Mann-Whitney test) using GraphPad Prism 9

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Stem Cell Research & Therapy

ISSN: 1757-6512