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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10

Fig. 4

BM-hMSC injection into the ovary restores fertility in LTZ-induced PCOS mouse model. a Morphology of ovary from a normal mouse (control), LTZ-induced PCOS mouse (PCOS), and BM-hMSC-treated PCOS mouse (BM-hMSC). Scale bar is 500μm. b Pregnancy rate of the control group (8 out of 10), PCOS group (1 out of 10), and BM-hMSC-treated group (8 out of 10). Graphs are presented as the mean ± SEM (n=10). c The mating index (Mating rate) of the control group, PCOS group, and BM-hMSC-treated group. Graphs are presented as the mean ± SEM (n=10). Morphology of pups and implantation site in the uterus of d control group, e PCOS group, and f BM-hMSC-treated group. g Average number of pups from the control group, PCOS group, and BM-hMSC group. Graphs are presented as the mean ± SD (n=3). h Average body weight of pups post-natal day 10. Graphs are presented as the mean ± SD (n=3). *p<0.05, ***p<0.0005; NS, not significant. Statistical significances were determined by 2-way ANOVA using GraphPad Prism 9

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