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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10

Fig. 5

BM-hMSC injection into the ovary reverses altered gene expression in ovarian tissue of LTZ-induced PCOS mice. Relative gene expression of a Cyp17a1, b Cyp19a1, c Fshr, and d Vegfa in the ovary from control, untreated PCOS, and BM-hMSC-treated PCOS mice. e Immunoblot of CYP17A1 and VEGFA in the ovary. Quantification of f CYP17A1 and g VEGFA in the ovary from control, PCOS, and BM-hMSC-treated PCOS mice. *p<0.05, **p<0.005, ***p<0.0005; NS, not significant. All graphs are presented as the mean ± SD (n≥3). Statistical significances were determined by 2-way ANOVA or nonparametric T-test (Mann-Whitney test) using GraphPad Prism 9

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Stem Cell Research & Therapy

ISSN: 1757-6512