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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells

Fig. 6

Cobblestone area-forming cells (CAFC) and colony-forming unit (CFU) produced by hematopoietic stem/progenitor cells (HSPC) before and after a 7-day expansion in a co-culture system with mesenchymal stromal cells (MSC) from different sources. a Fold increase of CAFC. b Total CFU obtained per 105 UCB cells. c Percentage of each CFU type (BFU-E, CFU-GM, CFU-Mix) produced. d Fold increase of total CFU. e Fold increase of each CFU type (BFU-E, CFU-GM, CFU-Mix). AT, adipose tissue; BFU-E, erythroid burst-forming unit; BM, bone marrow; CFU-GM, colony-forming unit granulocyte-monocyte; CFU-Mix, multilineage colony-forming unit; FBS, fetal bovine serum; FI, fold increase; FL, feeder layer; HPL, human platelet lysate; UCM, umbilical cord matrix. n = 3 for all conditions, with exception of ‘NO FL’: n = 2. Values are presented as mean ± SEM. **p < 0.01; *p < 0.05; #p < 0.01 vs BM-FBS, UCM-FBS, UCM-HPL, AT-FBS and p < 0.05 vs BM-HPL, AT-HPL

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