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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells

Fig. 2

The effect of hAECs on liver progenitor cell numbers and liver progenitor cell mitogens, IL-6, TWEAK and IFNγ. All mice on the NASH diet, (FF, FFHS and FFHD) had a significantly greater number of liver progenitor cells (LPC) compared with normal mice (a). Within the NASH diet groups, mice treated with a single dose of hAECs (FFHS) had significantly fewer LPCs than FF mice (a). Compared with FF mice, FFHS and FFHD mice had significantly lower expression levels of Il-6 (b), Tweak (c), and Ifnγ (d). Compared with normal mice, Il-6 gene expression was significantly lower in FFHS mice (b) and Ifnγ gene expression was significantly lower in mice treated with both a single and double dose of hAECs (d). Magnification: × 10, scale bar = 300 μm; red box indicating selected area at × 20 magnification (a). *P < 0.05, **P < 0.01, ***P < 0.001. FF, NASH diet alone; FFHD, NASH diet with double hAEC dose; FFHS, NASH diet with single hAEC dose

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Stem Cell Research & Therapy

ISSN: 1757-6512