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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells

Fig. 5

The effect of hAECs on hepatic IFN-β, STING levels and the c-GAS-STING pathway. Compared with normal mice, FFHS mice had significantly higher expression levels of IFN-β (a). Within the experimental NASH diet groups, only FFHS mice had significantly higher expression levels of Ifn-β (a). The Ifn-β expression levels were significantly higher in FFHS mice compared to FFHD mice. Compared with normal mice, FF, FFHS and FFHD mice had significantly higher expression levels of Sting (b). cGAS-STING activation was measured through Ifit1, Ifn-β and Rsad2 gene expression in iMACs and BMOLs co-cultured with hAECs. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) treated iMACs and BMOLs served as positive controls. Compared to untreated IMACs, there was no significant difference in Ifit1 (c), Ifn-β (d) and Rsad2 (e) in hAEC treated iMACs. Compared to untreated BMOLs, there was no significant difference in Ifit1 (f), Ifn-β (g) and Rsad2 (h) in hAEC treated BMOLs. *P < 0.05, **P < 0.01, **P < 0.001, ****P < 0.0001. iMACs, immortalised macrophages; BMOLS, bipotential murine oval liver cells

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Stem Cell Research & Therapy

ISSN: 1757-6512