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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy

Fig. 2

Hypoxic preconditioning augments the neuroprotection of OM-MSCs in ICH animal model. A Schematic representation of the experimental design for in vivo experiments. B The rotarod test and C the modified neurological severity score (mNSS) test were performed before ICH and at 7, 14, and 28 days after ICH. Data are expressed as the mean ± SEM (n = 7/group at 7 days; n = 5/group at 14 and 28 days) (***P < 0.001, P < 0.01 vs. sham-operated; #P < 0.05, ##P < 0.01 vs. ICH + saline; &P< 0.01 vs. ICH + Normoxia MSCs). D Quantification of neuronal specific nuclear protein (NeuN) and terminal transferase-mediated dUTP nick end labeling (TUNEL) double-stained cells. Data are expressed as the mean ± SEM (n = 4) (*P <0.05, **P <0.01, ***P <0.001, ns. no significance). E Representative images of TUNEL staining in ipsilateral cortex after ICH. The TUNEL and NeuN double-positive cells were indicated with white arrows

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