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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy

Fig. 9

Proposed mechanism for how hypoxic preconditioning rejuvenates OM-MSCs against ICH. In the microenvironment of ICH, the basal autophagy in normoxia OM-MSCs is insufficient, which accelerates the cellular senescence of transplanted OM-MSCs. Compared with normoxia OM-MSCs, hypoxic preconditioning upregulates the expression of miR-326 in OM-MSCs. miR-326 could promote autophagy by targeting PTBP1/PI3K signaling pathway. The sufficient autophagy can maintain OM-MSC functional survival. As a result, hypoxic preconditioning delays OM-MSC senescence and augments the therapeutic efficacy of OM-MSCs in ICH.

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Stem Cell Research & Therapy

ISSN: 1757-6512