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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci

Fig. 3

Effects of MSC-EVs on cell growth, migration, and chondrogenesis. A Chondrocytes cultured with or without MSC-EVs and stained with crystal violet. B CCK-8 cell growth assay in untreated and MSC-EV-treated chondrocytes. Absorbance is proportional to cell number. Measurements were repeated five times, and the average was recorded (n = 6). C Synovial MSCs cultured with and without MSC-EVs. D CCK-8 assay on synovial MSCs with and without MSC-EV treatment (n = 6). E Transwell assay showing the migration of chondrocytes with and without MSC-EV treatment. Chondrocytes migrating to the lower surface were counted in five randomly selected fields (n = 6). F Quantitation of migration by synovial MSCs with and without MSC-EV treatment (n = 6). G Macroscopic findings and histological Toluidine Blue staining of chondrogenic pellets of synovial MSCs with and without MSC-EV treatment. Pellets were weighed (n = 5; NS, no significant difference; P = 0.84). Data are the means ± SD. *P < 0.05 according to the Mann-Whitney U test

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