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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci

Fig. 4

Early effect of MSC-EVs in a mouse meniscal defect model. A Histology and IHC staining after 1 week in regenerated meniscus with and without MSC-EV treatment (n = 7). Samples were stained with HE, safranin-O/fast green, and proliferative cell nuclear antigen (PCNA) staining. B Semiquantitative evaluation by modified Pauli’s score (NS, no significant difference; P = 0.35). Three sections per knee were evaluated, and the average value was calculated. C Quantitative evaluation of MSC-EV-induced cell growth. The percentage of PCNA-positive cells in regenerated meniscus was estimated using three sections per knee, and the average was calculated (n = 7). Data are the mean ± SD. *P < 0.05 according to the Mann-Whitney U test

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