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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci

Fig. 5

Effects of MSC-EVs on gene expression in chondrocytes and synovial MSCs. A Volcano plot showing transcriptome/RNA sequencing data for chondrocytes cultured with and without MSC-EVs for 24 h (n = 4). Red dots represent upregulated DEGs, and blue dots represent downregulated DEGs. B Venn diagram of DEGs in chondrocytes and synovial MSCs. Genes common to both are listed in the table. C Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Bars represent Q, and lines represent candidate gene numbers. D Protein-protein interaction on “cytokine-cytokine receptor interaction” and “neuroactive ligand-receptor interaction” gene sets. Symbols for genes composing major clusters are shown in the table

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Stem Cell Research & Therapy

ISSN: 1757-6512