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Table 2 Laboratory data

From: Cell therapy in patients with COVID-19 using Wharton’s jelly mesenchymal stem cells: a phase 1 clinical trial

   Patient 1 Patient 2 Patient 3 Patient 4 Patient 5
Variables Normal Range Base line Day3 Day6 Day14 Base line Day3 Day6 Day14 Base line Day3 Day6 Day14 Base line Day3 Day6 Day14 Base line Day3 Day6 Day14
Routine blood tests
 WBC count (× 109/L) 3400–12,500 10940 14910 16710 14220 9600 7560 10620 8050 10400 11040 10950 11630 6100 12740 10050 9040 15106 14870 20850 24500
 Hb (g/L) M: 14–18
F: 12–16
12.1 12.7 15.1 13.7 11.5 11 11 13.5 13.1 14.2 13.5 15.1 14.7 15.1 14.4 13.8 13 13.4 14 9.3
 PLT count (× 109/L) 150,000–450,000 146 195 227 218 233 321 428 295 287 243 192 205 307 328 183 189 423 501 534 269
 Neutrophil (%) 45–75 NA 88 88 70 90 80 83 62 90 82 70 71 86 91 71 81 97 87 98 94
 Lymphocyte (%) 20–40 NA 2 10 19 4 9 11 26 5 10 20 20 8 2 21 14 3 5 2 2
 LYM count (× 109/L) 1.0–4.0 NA 298.2 1671 2701.8 384 680.4 1168.2 2093 520 1104 2190 2326 640 254.8 2110.5 1265.6 453.18 743.5 417 490
 ESR (mm/h) M: 0 to 20
F: 0 to 25
96 73 23 26 104 NA NA 51 74 9 25 10 37 5 64 17 80 50 NA 61
 D-Dimer (ng/ml) Up to 442 441 481 436 416 2071 1573 869 589 779 1234 11302 13321 15000> 12540 13214 10222 11321 11206 10278 9278
Myocardial enzymes
 CPK (U/L) 5 to 25 21.5 38 10 16.8 16 3.23 7.7 17.6 61 249 38 22 104 125 34 34 128 232 119 65
 Troponin I (ng/ml) ≤ 0.4 0.1 1.4 1.4 0.1 3.4 1.06 0.88 0.72 4.5 0.4 0.6 0.84 3.7 1.5 0.8 0.9 1.3 4.4 0.67 17.6
 LDH (U/L) 240–480 723 939 462 374 860 483 427 545 542 465 392 398 1458 1117 615 417 987 1182 1628 906
Biochemical indicators
 Total Bili (mg/dl) 0.1–1.2 0.26 0.7 1 0.6 1.1 0.54 0.43 0.9 0.7 0.6 0.7 1.3 1.6 1.6 1.6 0.9 4.55 4.3 2.6 1.3
 Direct Bili (mg/dl) Up to 0.3 0.1 0.3 0.3 0.1 0.3 0.2 0.02 0.1 0.1 0.1 0.2 0.2 1.2 0.6 0.3 0.2 0.41 0.8 0.6 0.3
 ALT (U/L) M: up to 41
F: up to 31
55 29 40 43 98 41 42 39 16 43 30 11 136 106 55 75 66 20 19 20
 AST (U/L) M: up to 38
F: up to 31
23.5 20 25 20 68 47.5 25 18 19 40 15 35 145 50 29 27 101 30 25 25
 BUN (mmol/L) 7–20 6 23 24 16 23 54 43 21 25.2 16 21 21 25 14 11 11 18 20 20 25
 Cr (μmol/L) M: 0.7–1.4
F: 0.6–1.3
0.8 0.8 0.7 0.8 0.5 0.9 1 1.1 0.9 0.8 1.1 0.9 0.8 0.7 0.8 0.7 1.03 0.9 0.9 1.1
 K (mmol/L) 3.6–5.2 4.1 4.8 4.8 NA 4.1 3.7 4.4 4.1 4.7 4.4 4.5 4.9 4.8 4.1 4.5 4.5 4.7 4.2 4.6 4.9
 Na (mEq/L) 135–145 139 137 138 NA 144 143 139 145 144 142 141 145 144 137 142 145 141 136 139 138
Inflammatory markers
 CRP (mg/L) Up to 10 60.5 6 3 0.48 107 101 20 3.84 87 53.5 24.5 4.44 45 82 35 1.47 60 29.5 72.5 49
 Procalcitonin (ng/ml) < 0.10 0.17 0.01 0.03 0.08 0.02 0.12 0.07 0.03 0.11 0.09 0.07 0.05 0.1 0.11 0.13 0.02 0.04 0.33 0.1 0.18
 Ferritin (ng/ml) M: 24 to 336
F: 11 to 307
1979 959 231 169 798 986 686 659 896 707 600 500 1087 2666 742 878 2314 1181 656 828