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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer’s disease

Fig. 5

Effects of hNTSC transplantation on cognitive deficit in 5 × FAD mouse brains. a The escape latency was the time for each group to find a hidden platform within 60 s. For the multiple comparison tests, two-way ANOVA was used to determine whether group differences were statistically significant. #P < 0.05, *P < 0.05, **P < 0.01, ***P < 0.001. b, c Probe test images of whether each group remembered the platform location in zone 4 during training. Data were expressed as the percentage (%) of time spent in each zone within 60 s. For the multiple comparison tests, two-way ANOVA test was used to determine whether group differences were statistically significant. *P < 0.05, **P < 0.01, ***P < 0.001. d Western blots of SDS-PAGE gels of brain tissue extracts of WT-sham, Tg-sham, Tg-hNTSC, and Tg-hBMSC mice using a primary anti-TIMP2 antibody at 7 weeks after stem cell transplantation. β-actin was used as a loading control. e Values are the mean (SD). For the nonparametric multiple comparison tests, one-way ANOVA was used to determine whether group differences were statistically significant. f TIMP-2 levels of hNTSCs and hBM-MSCs in culture, analyzed by TIMP-2 ELISA. Values are the mean (SD). Statistical differences between two different samples were determined with Student’s t test. **P < 0.01. All data are representative of two or three independent experiments

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