Fig. 5

Blockade of the IL-6 receptor after lethal ARS and subsequent LPS-EEMo treatment in vivo. A On day 0, female NSG mice received 4 Gy lethal total body irradiation and then 4 h later were treated with LPS-EEMos (n = 7) or PBS (n = 4). On days 2, 5, and 8, LPS-EEMo-treated mice were randomized to 250 μg anti-mouse IL-6R or isotype control antibodies. B On day 0, male NSG mice were as treated as above with 250 μg anti-mouse IL-6R (n = 4) or isotype control antibodies (n = 4). Survival was compared by log-rank analysis. *p < 0.05, **p < 0.01. C On day 0, female NSG mice were treated as in A except with 250 ug anti-mouse PD-1 or isotype control antibodies (iso)