Fig. 4
From: Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis
LLLT increasing angiogenesis in co-culture system of hBMSCs and HUVECs. A The representative tube formation images of HUVECs, hBMSCs, co-cultured HUVECs, and hBMSCs with or without LLLT (4.5 J/cm2 every day), scale bar, 500 μm. B Quantification of the junction number using Image J software. C, D The expression of the angiogenesis-related genes (VEGF, TGF-β, and HIF-1α) was measured by RT-qPCR at 3 days (C) and 7 days (D) under osteogenic induction (*P < 0.05, **P < 0.01, ***P < 0.001)