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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: A NOTCH1/LSD1/BMP2 co-regulatory network mediated by miR-137 negatively regulates osteogenesis of human adipose-derived stem cells

Fig. 7

A diagrammatic view of NOTCH1/LSD1/BMP2 signaling network in miR-137-mediated differentiation of hASCs towards osteoblastic lineage. In this complex network model, miR-137 modulates NOTCH1-HES1, LSD1, and BMP2-SMADs pathways simultaneously. Depending on the positive feedback loop between NOTCH1 and BMP2, as well as the negative reciprocal relationship between LSD1 and NOTCH1 or BMP2, the impacts of miR-137 on the above three signaling pathways are strengthened and the NOTCH1/LSD1/BMP2 network regulates the osteogenesis of hASCs coordinately (red lines represent downregulation and green lines represent upregulation)

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Stem Cell Research & Therapy

ISSN: 1757-6512