From: Mesenchymal stem cell therapy in pulmonary fibrosis: a meta-analysis of preclinical studies
Subgroup | Weighted mean (95% CI) | I2 | P |
---|---|---|---|
PF model | |||
 Bleomycin-induced PF model | −2.03 (−2.51, −1.56) | 82% | < 0.01 |
 Silica-induced PF model | −1.55 (−2.52, −0.57) | 0% | < 0.01 |
 Paraquat-induced PF model | −2.69 (−6.76, 1.37) | 99% | < 0.01 |
 Radiation-induced PF model | −1.00 (−1.83, −0.17) | NA | 0.02 |
MSC route | |||
 Intravenous injection | −2.77 (−2.83, −1.71) | 88% | < 0.01 |
 Non-intravenous injection | −0.83 (−1.23, −0.42) | 0% | 0.6 |
MSC type | |||
 BMSC | −1.22 (−1.68, −0.76) | 60% | < 0.01 |
 ADMSC | −1.98 (−2.79, −1.17) | 84% | < 0.01 |
 Others | −3.41 (−4.61, −2.22) | 91% | < 0.01 |
MSC dose | |||
 < 1.0 × 106 MSCs | −1.79 (−2.33, −1.25) | 83% | < 0.01 |
 ≥ 1.0 × 106 MSCs | −2.34 (−3.45, −1.23) | 93% | < 0.01 |
Time of MSC therapy | |||
 ≤ 1 d | −2.21 (−2.96, −1.47) | 92% | < 0.01 |
 >1 d | −1.83 (−2.59, −1.07) | 84% | < 0.01 |
Type of graft | |||
 Allograft | −1.58 (−2.25, −0.91) | 86% | < 0.01 |
 Xenograft | −2.55 (−3.40, −1.70) | 91% | < 0.01 |
Geographic location | Â | Â | Â |
 Asia | −2.03 (−2.84, −1.23) | 92% | < 0.01 |
 Europe | −1.79 (−2.95, −0.64) | 81% | < 0.01 |
 America | −1.79 (−3.65, −0.07) | 94% | < 0.01 |
 Oceania | −2.68 (−4.38, −0.98) | 85% | < 0.01 |