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Table 2 The study of correlation grouping and heterogeneity between pulmonary fibrosis scores and variables

From: Mesenchymal stem cell therapy in pulmonary fibrosis: a meta-analysis of preclinical studies

Subgroup

Weighted mean (95% CI)

I2

P

PF model

 Bleomycin-induced PF model

−2.03 (−2.51, −1.56)

82%

< 0.01

 Silica-induced PF model

−1.55 (−2.52, −0.57)

0%

< 0.01

 Paraquat-induced PF model

−2.69 (−6.76, 1.37)

99%

< 0.01

 Radiation-induced PF model

−1.00 (−1.83, −0.17)

NA

0.02

MSC route

 Intravenous injection

−2.77 (−2.83, −1.71)

88%

< 0.01

 Non-intravenous injection

−0.83 (−1.23, −0.42)

0%

0.6

MSC type

 BMSC

−1.22 (−1.68, −0.76)

60%

< 0.01

 ADMSC

−1.98 (−2.79, −1.17)

84%

< 0.01

 Others

−3.41 (−4.61, −2.22)

91%

< 0.01

MSC dose

 < 1.0 × 106 MSCs

−1.79 (−2.33, −1.25)

83%

< 0.01

 ≥ 1.0 × 106 MSCs

−2.34 (−3.45, −1.23)

93%

< 0.01

Time of MSC therapy

 ≤ 1 d

−2.21 (−2.96, −1.47)

92%

< 0.01

 >1 d

−1.83 (−2.59, −1.07)

84%

< 0.01

Type of graft

 Allograft

−1.58 (−2.25, −0.91)

86%

< 0.01

 Xenograft

−2.55 (−3.40, −1.70)

91%

< 0.01

Geographic location

   

 Asia

−2.03 (−2.84, −1.23)

92%

< 0.01

 Europe

−1.79 (−2.95, −0.64)

81%

< 0.01

 America

−1.79 (−3.65, −0.07)

94%

< 0.01

 Oceania

−2.68 (−4.38, −0.98)

85%

< 0.01