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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

Fig. 1

EGR1 transcription factor is overexpressed in aged human hematopoietic stem cell-enriched compartment: from A to I: single-cell analysis performed on dataset GSE104379 processing HSC-enriched compartment (HSC) equivalent to lineage –/CD34+/CD38– human cell compartment; A tSNE analysis of young and old HSC single-cell transcriptome, B tSNE analysis of young and old HSC single-cell transcriptome stratified by genders; C expression level of EGR1 in tSNE analysis of HSC; D expression level of CDK6 in tSNE analysis of HSC; E ridge plot comparing expression of CDK6 and EGR1 stratified on the age of donors; F violin plot of EGR1 expression stratified on age and gender of donors; G cell cycle analysis stratified on age of donors; H barplot of cell cycle phase stratified according to the age of donors (white numbers represent the number of cells classified in each phase); I ridgeplot of CDK4, CDK6, and CCND2 expressions according to cell cycle phases according age of donors

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Stem Cell Research & Therapy

ISSN: 1757-6512