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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

Fig. 2

During aging, EGR1 cell trajectory in human HSC shows an activation of transcription factors implicated in inflammation: from A to F: single-cell analysis performed on dataset GSE104379 processing HSC-enriched compartment (HSC) equivalent to lineage –/CD34+/CD38– human cell compartment: A EGR1 expression in t-SNE analysis stratified on age groups, B barplot of cell stratification between age group and EGR1 expression relative groups (EGR1 low and EGR1 high expression with threshold on value of 3), C single-cell pseudotime transformation based on EGR1 expression, D EGR1 expression-based cell trajectory stratified on groups of age, E pseudotime heatmap of best markers which followed pseudotime transformation based on EGR1 expression level in HSC, and F some transcription factors and molecules found in EGR1 cluster after pseudotime transformation

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