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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

Fig. 3

EGR1 gene connected network confirms the phenotype relation with age in HSC human cell compartment: from A to E process of RNA-sequencing from dataset GSE104406; A volcano plot of differential expressed genes in RNA-sequencing transcriptome of old HSC versus young HSC, B expression level of EGR1 stratified on age groups, C power analysis for WGCNA analysis performed on EGR1-dependent signature in human HSC, D TOM topological heatmap of gene modules identified during WGCNA analysis with EGR1-dependent signature in human HSC, E multidimensional scaling plot of genes classed by modules during WGCNA analysis, F expression heatmap of genes stratified by modules during WGCNA analysis, and G module correlation to phenotype (correlation score with p as relative p values)

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