Fig. 5

EGR1-dependent old-specific gene network module in human HSC: A Gene connections identified in old HSC compartment during EGR1-dependent WGCNA analysis (node and color nodes are proportional of node centrality, color, and size of the edge are proportional of edge centrality); B Network analysis in old HSC module with a number of direct edges on the first axis and logarithm base 10 of betweeness centrality and neighborhood connectivity for the size of the gene points; C misclassification error graph obtained in age-supervised machine learning with genes of old HSC module; D barplot of predictive scores for predictive markers of young HSC; and E expression dotplot showing in individual samples the expression of best predictive markers of old HSC