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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

Fig. 8

EGR1 expression and age relations in human long-term hematopoietic stem cells of healthy donors and that of acute myeloid leukemia patients: A scatterplot of age versus EGR1 expression in human bone marrow hematopoietic compartments of healthy donors; B scatterplot of age versus EGR1 expression in human bone marrow hematopoietic compartments of healthy donors; C boxplot of EGR1 expression in the different hematopoietic compartment (STHSC, short-term HSC; MPP, multipotent progenitor; MLP, multi-lymphoid progenitor; MEP, megakaryocyte erythrocyte progenitor; LTHSC, long-term HSC; LSC, leukemic stem cell; LPC, leukemic progenitor cell; linnegRA, Lin-CD34+CD38-CD90-CD45RA+ from cord blood; GMP, granulocyte myeloid progenitor; CMP, common myeloid progenitor; AML34P38P, compartment CD34+CD38+ of AML samples; 34neg, compartment of CD34− cells; D Boxplot of EGR1 expression in LT-HSC, ST-HSC, and GMP stratified on karyotype status (normal versus monosomy 7)

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