Skip to main content

Table 1 Clinical characteristics and outcome of patients

From: Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study

Patient

Age (years)

Symptoms

Etiology of AS (times)

Prior repair attempts

Score of AS at 1st HSA

Previous treatment received

ET (pre-/post-therapy mm)

Pregnancy outcome

P1

39

Infertility (3 years)

Hypomenorrhea

5 D&C

3 HSA

AS Stage II

Estrogen/Aspirin/Heparin/GH/Sildenafil/traditional Chinese medicine

5.5/7.1

2 FET and implantation failure

P2

33

Infertility (3 years)

Hypomenorrhea

1 D&C

3 HSA

AS Stage III

Estrogen/Aspirin/Heparin/Sildenafil

3/6.1

1 FET and implantation failure

P3

30

Infertility (4 years)

Hypomenorrhea

1 HSP

1 D&C

5 HSA

AS Stage IV

Estrogen/Aspirin/Heparin/GH /Sildenafil/G-CSF/GM-CSF/traditional Chinese medicine

5.1/6.6

3 FET and implantation failure

P4

37

Infertility (3 years)

6 D&C

2 HSA

AS Stage IV

Estrogen/Aspirin/Heparin/GH /G-CSF

5.1/5.9

1 FET and implantation failure

P5

34

Infertility (3 years)

Hypomenorrhea

2 D&C

2 HSA

AS Stage II

Estrogen/Aspirin/traditional Chinese medicine

5.2/5.8

1 FET 4 months post-treatment and cesarean section at 35 + 5 weeks, girl,1950 g

P6

34

Infertility (6 years)

Hypomenorrhea

2 D&C

5 HSA

AS Stage IV

Estrogen/Aspirin/Heparin/GH/Sildenafil

2.3/6.1

1 FET and implantation failure

P7

35

Infertility (4 years)

Hypomenorrhea

4 D&C

4 HSA

AS Stage II

Estrogen/Aspirin/Heparin/GH/G-CSF

5.1/6.4

2 FET and implantation failure

P8

35

Infertility (4 years)

Hypomenorrhea

1 D&C

3 HSA

AS Stage III

Estrogen/Aspirin/Heparin

4.5/6.6

1 FET 2 months post-treatment and abortion at 25+ weeks

P9

39

Infertility (6 years)

Hypomenorrhea

1 D&C

3 HSA

AS Stage IV

Estrogen/Aspirin/Heparin/GH/Sildenafil

3.7/5

2 FET and implantation failure

P10

30

Infertility (1 year)

Hypomenorrhea

4 D&C

2 HSA

AS Stage III

Estrogen/Aspirin/Heparin/Sildenafil

3.5/4.5

Spontaneous pregnancy 9 months post-treatment and natural labor at 39 weeks, boy, 2600 g

P11

37

Infertility (3 years)

Hypomenorrhea

3 D&C

2 HSA

AS Stage IV

Estrogen/Aspirin/Heparin

4.5/-

Did not measure ET after treatment and no FET

P12

36

Infertility (4 years)

Hypomenorrhea

3 D&C

3 HSA

AS Stage III

Estrogen/Aspirin

3.4/5.8

1 FET and implantation failure

P13

31

Infertility (5 years)

Hypomenorrhea

2 D&C

3 HSA

AS Stage IV

Estrogen/Aspirin/Heparin/Sildenafil/G-CSF

4.9/6.4

2 FET and implantation failure

P14

33

Infertility (5 years)

Hypomenorrhea

8 D&C

4 HSA

AS Stage III

Estrogen/Aspirin/Heparin/Sildenafil

4.2/5.9

2 FET and implantation failure

P15

26

Infertility (5 years)

Amenorrhea

2 D&C

5 HSA

AS Stage VA

Estrogen/Aspirin/Heparin/Sildenafil

2.5/4.7

1 FET and implantation failure

P16

37

Infertility (2 years)

Hypomenorrhea

1 D&C

3 HSA

AS Stage IV

Estrogen/Aspirin/Heparin

3.5/-

Withdrew

P17

32

Infertility (1 years)

Amenorrhea

1 D&C

3 HSA

AS Stage Va

Estrogen/Aspirin/Heparin

4.4/6.3

1 FET 3 months post-treatment and natural labor at 40 + 1 weeks, girl, 2900 g

P18

39

Infertility (12 years)

1 D&C

3 HSA

AS Stage IV

Estrogen/Aspirin/Heparin/G-CSF

3/4.7

1 FET and implantation failure

  1. P, patient; D&C, dilatation and curettage; HSP, hysteroscopic polypectomy; HSA, hysteroscopic adhesiolysis; AS, Asherman, syndrome; ET, endometrial thickness; GH, growth hormone; G-CSF, granulocyte colony-stimulating factor; FET, frozen–thawed embryo transfer