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Table 3 Summary of research on human stem cell therapy for thin endometrium

From: Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study

Author Year Number of patients Type of stem cell Intervention Method of stem cell administration ET (pre-/post-therapy) Pregnancy outcome
Nagori et al. a 2011 1 AS Auto-BMSCs Stem cell therapy Intrauterine infusion 3.2/7.1 8 weeks
N Singh et al. b 2014 6 AS (5/6 genital TB) BM-MNCs Stem cell therapy Subendometrial zone injection 1.38/4.05/5.46/5.48 N/A
X Santamaria et al. b 2016 11 AS
5 EA
Auto-CD133 + BMSCs HSA + stem cell therapy Uterine spiral arterioles IUA improve obviously.
EM for AS:4.3/6.7
EM for EA:4.2/5.7
2 babies born, 2 ongoing pregnancy, 2 miscarriage, 1 ectopic, 3 biochemical pregnancy
Jichun Tan et al. b 2016 7 AS Auto-MenSCs Stem cell therapy Intrauterine infusion EM :3/7 2 babies born, 1 ongoing pregnancy
Guangfeng Zhao et al. b 2017 5 AS Auto-MNCs HSA + stem cell therapy Loaded onto a collagen scaffold IUA improve obviously.
EM:4.5/7.2
5 babies born
Yun Cao et al. b 2018 26 AS UC-MSCs HSA + stem cell therapy Loaded onto a collagen scaffold IUA score:9.12/5.52
EM:4.46/5.74
8 babies born, 1 ongoing pregnancy, 1 miscarriage
Se Yun Lee et al. b 2019 6 AS Auto-ADSCs Stem cell therapy Intrauterine infusion EM:3.0/6.9 1 miscarriage
N Singh et al. b 2020 12 AS (9/12 genital TB)
13 EA (6/13 genital TB)
BM-MNCs HSA + stem cell therapy Subendometrial zone injection IUA improve.
EM for AS:2.6/4.2/4.6
EM for EA:3.6/5.9/6.5
3 babies born (all have no genital TB)
  1. aCase report. bProspective study. AS, Asherman syndrome; EA, endometrial atrophy; BMSCs, bone marrow mesenchymal stem cells; MNCs, mononuclear cells; MenSCs, menstrual endometrial stem cells; ADSC, adipose-derived stem cells; IUA, intrauterine adhesions