Table 3 Summary of research on human stem cell therapy for thin endometrium
Author | Year | Number of patients | Type of stem cell | Intervention | Method of stem cell administration | ET (pre-/post-therapy) | Pregnancy outcome |
|---|---|---|---|---|---|---|---|
Nagori et al. a | 2011 | 1 AS | Auto-BMSCs | Stem cell therapy | Intrauterine infusion | 3.2/7.1 | 8 weeks |
N Singh et al. b | 2014 | 6 AS (5/6 genital TB) | BM-MNCs | Stem cell therapy | Subendometrial zone injection | 1.38/4.05/5.46/5.48 | N/A |
X Santamaria et al. b | 2016 | 11 AS 5 EA | Auto-CD133 + BMSCs | HSA + stem cell therapy | Uterine spiral arterioles | IUA improve obviously. EM for AS:4.3/6.7 EM for EA:4.2/5.7 | 2 babies born, 2 ongoing pregnancy, 2 miscarriage, 1 ectopic, 3 biochemical pregnancy |
Jichun Tan et al. b | 2016 | 7 AS | Auto-MenSCs | Stem cell therapy | Intrauterine infusion | EM :3/7 | 2 babies born, 1 ongoing pregnancy |
Guangfeng Zhao et al. b | 2017 | 5 AS | Auto-MNCs | HSA + stem cell therapy | Loaded onto a collagen scaffold | IUA improve obviously. EM:4.5/7.2 | 5 babies born |
Yun Cao et al. b | 2018 | 26 AS | UC-MSCs | HSA + stem cell therapy | Loaded onto a collagen scaffold | IUA score:9.12/5.52 EM:4.46/5.74 | 8 babies born, 1 ongoing pregnancy, 1 miscarriage |
Se Yun Lee et al. b | 2019 | 6 AS | Auto-ADSCs | Stem cell therapy | Intrauterine infusion | EM:3.0/6.9 | 1 miscarriage |
N Singh et al. b | 2020 | 12 AS (9/12 genital TB) 13 EA (6/13 genital TB) | BM-MNCs | HSA + stem cell therapy | Subendometrial zone injection | IUA improve. EM for AS:2.6/4.2/4.6 EM for EA:3.6/5.9/6.5 | 3 babies born (all have no genital TB) |