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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Pretreatment of cardiac progenitor cells with bradykinin attenuates H2O2-induced cell apoptosis and improves cardiac function in rats by regulating autophagy

Fig. 5

BK-preconditioned hCPCs reduced myocardial inflammation, fibrosis, and cell apoptosis in MI rats. Representative images (A) and quantitative analysis (B) of H&E staining 6 weeks after MI in the sham group (Sham), MI rats treated with the PBS group (PBS), MI rats transplanted with the hCPC-negative cell group (hCPC- cells), MI rats transplanted with the hCPC group (hCPCs), MI rats transplanted with the BK-treated hCPC group (BK-hCPCs), and MI rats transplanted with the 3-MA-treated hCPC group (3-MA-hCPCs). Representative images (C) and quantitative analysis (D) of Masson’s staining 6 weeks after MI. Representative protein expression (E) and quantitative analysis (F) of TUNEL staining in corresponding groups. (Data are shown as mean ± SEM, n = 6, **P < 0.01 VS. Sham; #P < 0.05, ##P < 0.01 VS. MI; &P < 0.05, &&P < 0.01 VS. CPCs-MI.)

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Stem Cell Research & Therapy

ISSN: 1757-6512