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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cell-derived extracellular vesicles as probable triggers of radiation-induced heart disease

Fig. 5

Effects of hp-MSC-derived EVs on tube formation of HUVEC cells and calcium transient of H9c2 cells. A Representative images of vessel-like structure formation on Matrigel®. HUVEC cells were previously cocultured with 10 μg/ml EVs from non-irradiated/irradiated hp-MSCs or not for 48 h. Scale bar: 200 μm. B, C Quantitative data (n=3) on tube formation relative to nontreated cells. D Quantitative analyses (n=3) of the calcium fluorescence intensity in H9c2 cells cocultured with 10 μg/ml EVs from non-irradiated/irradiated hp-MSCs or not for 48 h. Non-irradiated-EVs: EVs isolated from conditioned medium of non-irradiated hp-MSCs, irradiated-EVs: EVs isolated from conditioned medium of irradiated hp-MSCs. Values are the mean ± SD. ns P > 0.5, *P < 0.5, **P < 0.1

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