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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model

Fig. 7

Let-7b promotes aggrecan expression by targeting ADAMTS5 in vitro. a Chondrocytes with let-7b knockdown were transfected with siRNA-ADAMTS5, and transfection efficiency was evaluated by real-time PCR (n = 6, Student’s t test). b, c Protein expression of aggrecan, COL2A1, and ADAMTS5 in chondrocytes after knocking down ADAMTS5 (n = 3, Student’s t test). d, e Protein immunofluorescence intensity of aggrecan, COL2A1, and ADAMTS5 in each group (n = 3, one-way ANOVA). a, c, e Values are presented as mean ± SD. **P < 0.01, ***P < 0.001, Student’s t test and one-way ANOVA

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Stem Cell Research & Therapy

ISSN: 1757-6512