Skip to main content
Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model

Fig. 8

Let-7b promotes aggrecan expression by targeting ADAMTS5 in vivo. a Safranin-O, Fast Green, and immunofluorescence staining of each group of mouse knee section. b OARSI scores for each group (n = 6, Student’s t test). c Protein immunofluorescence intensity of aggrecan, COL2A1, and ADAMTS5 in each group (n = 6, Student’s t test). d let-7b in LPS-pre EVs directly targets and binds ADAMTS5, inhibits ADAMTS5 expression, and thus inhibits aggrecan and COL2A1 degradation. b, c Values are presented as mean ± SD. NS, *P < 0.05, **P < 0.01, Student’s t test

Back to article page