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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells

Fig. 6Fig. 6

PPI network and hub genes were discovered among DMEGs. a PPI network of DMEGs. Blue represents the hypermethylated and upregulated genes, yellow represents the hypomethylated and downregulated genes, green represents the hypermethylated but downregulated genes, and red represents the hypomethylated but upregulated genes. b The hyper-up cluster and the GO enrichment analysis for DMEGs in this cluster. c The hypo-down cluster and the GO enrichment analysis for DMEGs in this cluster. d The hyper-down cluster and the GO enrichment analysis for DMEGs in this cluster. e The hypo-up cluster and the GO enrichment analysis for DMEGs in this cluster. f Hub genes calculated from the PPI network of DMEGs. The size and color of the nodes are proportional to the combining score. g Data visualization of VEGFA, CD44, MMP2, HGF, and SPARC mRNA m6A modification in uhASCs and dhASCs. h qRT-PCR analyses of the expression of hub DMEGs of VEGFA, CD44, MMP2, HGF, and SPARC. *p < .05, **p < .01, ***p < .001. PPI, protein-protein interaction; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DMEGs, differentially methylated and expressed genes; hyper-up, hypermethylated and upregulated genes; hypo-down, hypomethylated and downregulated genes; hyper-down, hypermethylated and downregulated genes; hypo-up, hypomethylated and upregulated genes; hASCs, human adipose-derived stem cells; uhASCs, undifferentiated hASCs; dhASCs, osteogenically differentiated hASCs; qRT-PCR, quantitative real-time polymerase chain reaction

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