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Table 3 ASIA and SCIM III scores at different time points

From: Combining cell therapy with human autologous Schwann cell and bone marrow-derived mesenchymal stem cell in patients with subacute complete spinal cord injury: safety considerations and possible outcomes

Score subject Population Time Mean SD p-value
ASIA Motor score Total study population Before injection 37.54 17.58
After 6 months 40.45 14.80 0.068
After 12 months 41.00 14.58 0.066
Thoracic patients Before injection 50.00 00.00
After 6 months 51.00 2.64 0.317
After 12 months 51.28 3.40 0.317
Cervical patients Before injection 15.75 5.90
After 6 months 22.00 1.63 0.109
After 12 months 23.00 2.58 0.109
Light touch Total study population Before injection 47.63 24.37
After 6 months 50.54 24.46 0.042*
After 12 months 51.80 25.74 0.027*
Thoracic patients Before injection 60.57 19.51
After 6 months 63.71 17.12 0.109
After 12 months 68.00 16.44 0.068
Cervical patients Before injection 25.00 12.05
After 6 months 27.50 15.00 0.180
After 12 months 27.50 15.00 0.180
Pin prick Total study population Before injection 48.54 25.66
After 6 months 51.63 25.71 0.041*
After 12 months 53.00 27.00 0.027*
Thoracic patients Before injection 62.00 20.81
After 6 months 65.42 19.13 0.102
After 12 months 70.00 17.15 0.066
Cervical patients Before injection 25.00 12.09
After 6 months 27.50 15.86 0.180
After 12 months 27.50 15.86 0.180
SCIM III Total score Total study population Before injection 28.9 12.99
After 6 months 37.54 18.40 0.012*
After 12 months 43.10 25.77 0.018*
Thoracic patients Before injection 37.14 6.28
After 6 months 49.28 7.08 0.018*
After 12 months 60.50 14.18 0.028*
Cervical patients Before injection 14.50 7.00
After 6 months 17.00 12.00 0.317
After 12 months 17.00 12. 00 0.317
Self-care Total study population Before injection 8.00 5.53
After 6 months 10.36 6.74 0.043*
After 12 months 11.40 7.93 0.005**
Thoracic patients Before injection 11.71 2.49
After 6 months 14.71 2.98 0.068
After 12 months 17.16 2.48 0.042*
Cervical patients Before injection 1.50 1.00
After 6 months 2.75 3.50 0.317
After 12 months 2.75 3.50 0.317
Respiration and sphincter management Total study population Before injection 17.18 5.89
After 6 months 21.72 8.22 0.016*
After 12 months 26.20 13.63 0.027*
Thoracic patients Before injection 19.57 4.64
After 6 months 26.00 4.24 0.026*
After 12 months 34.16 10.04 0.043*
Cervical patients Before injection 13.00 6.00
After 6 months 14.25 8.50 0.317
After 12 months 14.25 8.50 0.317
Mobility Total study population Before injection 3.72 3.58
After 6 months 5.45 4.78 0.039*
After 12 months 8.90 12.81 0.043*
Thoracic patients Before injection 5.85 2.60
After 6 months 8.57 2.63 0.039*
After 12 months 14.83 13.77 0.043*
Cervical patients Before injection 0.00 0.00
After 6 months 0.00 0.00 1.00
After 12 months 0.00 0.00 1.00
  1. Bold values indicate statistical significance (*p-value ≤ 0.05; **p-value ≤ 0.01)