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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition

Fig. 1

UCB-MSC-exo accelerate wound closure and suppress scar formation in full-thickness skin-wounded rats. A Schematic representation of UCB-MSC-exo preparation. B UCB-MSC-exo particle size was measured using NanoSight. C Morphological characteristics of UCB-MSC-exo were measured using transmission electron microscopy (scale bar = 100 nm). D Exosomal markers of UCB-MSC-exo were measured via western blot. E Schematic representation of animal experiments. The full-thickness excisional wound (12 mm diameter) was created on the dorsal region. The rats were then administered by tail vein injection every week: PBS (control group), UCM-MSCs (2 × 106 cells), or UCB-MSC-exo (20 μg). F Morphological changes during wound healing; scale bar = 5 mm. G Changes in the wound area during wound healing. *p < 0.05; **p < 0.01; means ± SD; n = 5

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