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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition

Fig. 4

UCB-MSC-exo suppress myofibroblast formation. A IF staining of α-SMA and collagen I in the wound healing skin; scale bar = 300 μm. B, C mRNA levels of α-SMA and Col1a2 in the wound healing skin. HDFs were cultured for 48 h with TGF-β1 (25 ng/ml) to induce myofibroblast differentiation. Some cells were also treated with UCB-MSC-exo (25 ng/ml). DF IF staining and qRT-PCR analysis of α-SMA and collagen I in HDFs; scale bar = 100 μm. *p < 0.05; **p < 0.01; ***p < 0.001; means ± SD; n = 3

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