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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition

Fig. 8

UCB-MSC-exo improve regenerative wound healing and suppress scar formation by inhibiting the expression of TGF-β receptors. When UCB-MSCs are transplanted into the skin wound, multiple vesicles bud from the plasma membrane, releasing the exosomes into the extracellular space where they then fuse with the plasma membrane of receptor cells. UCB-MSC-exo, carrying cargos of proteins, and RNAs, can travel to and be internalized by recipient cells (HDFs). Then, UCB-MSC-exo-derived specific miRNAs (such as miR-21-5p and miR-125b-5p) can regulate gene expression in HDFs. miR-21-5p targets TGFBR2, whereas miR-125b-5p targets TGFBR1, thereby suppressing myofibroblast differentiation, and ultimately reducing scar formation and promoting regenerative wound healing

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