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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell differentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity

Fig. 1

Changes of myelin sheath in the spinal cord of HD-exposed rats with or without BMSCs. a Schematic diagram of experimental design. SD rats were intraperitoneally injected with HD (400 mg/kg in saline) or saline for 5 consecutive weeks (5 times per week) to induce demyelinating damage. Then, rats were grafted with 5 × 107/kg body weight BMSCs by tail vein injection and observed for another 5 weeks for remyelinating recovery. Control group: rats received normal saline (NS) i.p. injection and NS i.v. injection; BMSCs group: rats received normal saline (NS) i.p. injection and BMSCs i.v. injection; HD group: rats received HD i.p. injection and no further treatment; HD + NS group: rats received HD i.p. injection and NS i.v. injection; HD + BMSC group: rats received HD i.p. injection and BMSC i.v. injection; b representative electron-microscope images of spinal cord. Yellow arrows represent normal myelin, red arrows represent structurally deranged myelin, featuring with segmental loss and separation of myelin sheath and vacuole-like denaturation (red star), and Green arrows represent recovered myelin sheath structure following BMSCs treatment. c Luxol fast blue (LFB)-stained images. Scale bar, 50 μm. d Quantification of LFB+ area. Quantified data are shown as mean ± SD. a: Compared with control group, p < 0.05; b: compared with HD group, p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512