Fig. 2
From: Translational models of 3-D organoids and cancer stem cells in gastric cancer research
Schematic representation of mouse gastric corpus gland. In mouse gastric corpus, two different stem cell population such as isthmus stem cells (IsthSCs) and base stem cells included Troy+ and Lgr5+ cells are maintained [4]. IsthSCs are multi-potent and cycling actively and maintaining the pit-isthmus-neck regions through a process of stochastic self-renewal. IsthSCs are localized between pit and neck and are characterized as expressions of Stmn1 and Ki 67. As IsthSCs move to displace upward or downward from the Isthmus region and become sub-lineage restricted with co-expression of lower Muc5aca and Muc6 before terminal differentiation into the respective cell types, the gland base is maintained by TROY+ or LGR5+ (Chief) stem cells, which are mostly quiescent