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Table 1 CPP-conjugated therapeutics in clinical trial

From: Prospect of cell penetrating peptides in stem cell tracking

Disease

CPP-cargo

Number of enrolled patients

Status

ClinicalTrials.gov ID

Solid tumors

P28

N = 15

Phase I completed 2014

NCT00914914

CNS malignancies

P28

N = 18

Phase I completed 2017

NCT01975116

Postherpetic neuralgia

TAT-ɛPKC inhibitor

N = 23

Phase II completed 2011

NCT01106716

Acute inner ear hearing loss

TAT-AM 111

N = 256

Phase III completed 2017

NCT02561091

Tumor imaging

ACPPs-Cy5 and Cy7

N = 27

Phase I completed 2017

NCT02391194

Cervical dystonia

TAT-Daxibotulinumtoxin A

N = 37

Phase II completed 2019

NCT02706795

Postoperative ocular inflammation

TAT-XG102

N = 339

Phase III completed 2017

NCT02235272