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Table 1 Surface marker phenotype and in vitro/in vivo differentiation of human endometrial stem cells

From: Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis

Cell type

Positive marker

Negative marker

In vitro and in vivo differentiation

References

MenSCs

CD73, CD90, CD105, CD13, CD44, CD29, CD9, CD44, CD41a, CD59

CD19, CD34, CD45, CD117, CD130, HLA-DR

Adipocytes, osteocytes, cardiomyocytes, neurocytes, respiratory epithelial cells, endothelial cells, myocytes, hepatic cells, pancreatic cells, and germ-like cell

[42, 43]

Endometrial SPs of epithelial origin

CD9, CD90, CD105, CD73, CD45, CD34, CD31, CD133, stro-1

CD9, CD13

Adipocytes, osteocytes

[96, 97]

Endometrial SPs from the stromal compartment

Vimentin, CD90, CD73, CD45, CD34, CD31, CD133, stro-1

CD9, CD13, CD105, ERα, PR

Adipocytes, osteocytes

[97]

SUSD2+ eMSCs

CD29, CD44, CD73, CD90, CD105, CD117, CD140b, CD146, and STRO-1, NTPDase2

CD31, CD45

Adipocytes, osteocytes, chondrocytes, myocytes, endothelial cells

[12]

CD140b+CD146+ eMSCs

CD29, CD44, CD73, CD90, CD105, CD140b, CD146

CD31, CD34, CD45

Osteocytes, myocytes, adipocytes, chondrocytes, fibroblasts and smooth muscle cell

[12, 14, 15]

CD146+ cells

CD10, CD13, CD44, CD73, CD90, and CD105

CD31, CD34, CD45, CD56, CD144, CD9

Adipocytes, osteoblasts, and neuron-like cells, glial-like cells

[19, 21]

Epithelial stem/progenitor cells

N-cadherin, SSEA-1, Axin 2

 

Entire complement of glandular lineages, endometrial organoids

[104, 107, 150]

  1. MenSCs menstrual stem cells, SPs side population cells, eMSCs endometrial mesenchymal stem cells