Fig. 6

The crosstalk among the survival signaling pathways. Each of the signals emerge as the regulators involved in the fate of HFSCs and these pathways (Notch, BMP, Wnt, Shh, etc.) emerge as a network in the life of HFSCs at the same time or in different period. Such as Dlx3, it is a homeobox transcription factor which could not only place downstream of Wnt through Lef targeting and causing a loss of BMP signaling. Moreover, Shh could up-regulate dermal noggin expression; which is a potent inhibitor of BMP signaling. The solid arrows indicate the targeting work from one of molecules involved in the signaling targeting to other signal pathways