Fig. 6

Skeletal muscle regeneration after human bone marrow mesenchymal stromal cell (hMSC) transplantation. The hMSCs were cultured under normoxic (NORM) or hypoxic (HYPO) conditions and injected into cardiotoxin (CTX) injured muscles. A Skeletal muscle weight, the area of connective tissue, blood vessels, nerves, and frequency of new myofibers in intact muscles or muscles injured (CTX) and transplanted with hMSC cultured either under normoxic (NORM) or hypoxic (HYPO) conditions. B Histology of intact muscles or in muscles injured (CTX) and transplanted with hMSC cultured under normoxic (NORM) or hypoxic (HYPO) conditions. C Localization of transplanted cells (blue—nuclei, red—laminin, green—human nuclei) in intact muscles or muscles injured (CTX) and transplanted with hMSC cultured under normoxic (NORM) or hypoxic (HYPO) conditions. D Expression of selected mouse transcripts in intact muscles or muscles injured (CTX) and transplanted with hMSC cultured under normoxic (NORM) or hypoxic (HYPO) conditions. E Expression of selected human transcripts in intact muscles or muscles injured (CTX) and transplanted with hMSC cultured under normoxic (NORM) or hypoxic (HYPO) conditions. P value: *< 0.05; **< 0.01; ***< 0.001; ****< 0.0001