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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Melatonin contributes to the hypertrophic differentiation of mesenchymal stem cell-derived chondrocytes via activation of the Wnt/β-catenin signaling pathway

Fig. 2

Melatonin promotes hypertrophic gene expression in the stem cells derived chondrocytes. a–f The mRNA expression of collagen type X (COL10A1) (A), runt-related transcription factor 2 (RUNX2) (b), parathyroid hormone-related protein receptor (PTHrP-R) (c), alkaline phosphatase (ALP) (d), Indian hedgehog (IHH) (e), and parathyroid hormone-related protein (PTHrP) (f) in BMSC-derived chondrocytes treated as indicated. g–j The mRNA expression of COL10A1 (g), RUNX2 (h), PTHrP (i), and IHH (j) in C3H10T1/2 -derived chondrocytes. Gene expressions were normalized to GAPDH mRNA. *P < 0.05; **P < 0.001; ns, not significant

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Stem Cell Research & Therapy

ISSN: 1757-6512