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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Melatonin contributes to the hypertrophic differentiation of mesenchymal stem cell-derived chondrocytes via activation of the Wnt/β-catenin signaling pathway

Fig. 7

Wnt/β-catenin signaling pathway inhibitor blocks melatonin-mediated enhancement of hypertrophy. a Immunohistochemical staining of Col-X in MSC-derived cartilage. Scale bar = 200 μm. b Quantitative analysis of Col-X staining of the MSC-derived cartilage. c–e The mRNA expressions of RUNX2 (c), COL10A1 (d), and IHH (e) in the C3H10T1/2-derived chondrocytes. Gene expressions were normalized to that of GAPDH mRNA. *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512