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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Fig. 7

a Immunofluorescence staining of Tuj-1. Scale bars = 200 and 50 μm. The number of Tuj-1-positive cells was higher in the bFGF-HUCMSC group compared with the control and HUCMSC groups in the perilesional area of the injury site. b Immunofluorescence staining of both Ki67 and Nestin. Scale bars = 200 and 50 μm. The number of Ki67/Nestin-positive cells was higher in the bFGF-HUCMSC group compared with the control and HUCMSC groups in the perilesional area of the injury site. c Quantification of Tuj-1 staining in control, HUCMSC, and bFGF-HUCMSC groups. ***p < 0.001). d Quantification of Ki67/Nestin-positive staining. ***p < 0.001. e EDU staining of NSCs in vitro. Scale bars = 100 μm. f Immunofluorescence staining of Tuj-1 (green) and GFAP (red) in NSCs in vitro. Scale bars = 75 μm. g The number of EDU-positive cells in the bFGF-HUCMSC group was higher than that in the other two groups. *p < 0.05 and ***p < 0.001. h The number of neurons in the bFGF-HUCMSC group was higher than that in the other two groups. **p < 0.01 and ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512