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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates

Fig. 2

Safety of sub-retinal transplant photoreceptor precursors into naïve NHP eyes. A Photoreceptor precursors were transplanted subretinally in yellow circle zone (colour fundus, Column A1, and autofluorescence images, Column A2) in naïve NHP eyes and followed at 2 days, 1, 2 and 3 months post-transplantation. Limited changes were observed at transplantation zone on autofluorescence images and showed time-dependent recovery. OCT line scan images on transplantation zone (Column A3, indicated as yellow arrows in Column A2) showed interrupted ONL at retinal incision site (red arrows) at day 2 and recovered during follow up. Normal macula structures were shown on OCT scans (Column A4) as indicated the scanned position at white arrows in Column A2. B Histology images (H&E) on transplantation zone and macula both showed normal retinal structure. Scale bar, 200 μm in Column A3 and A4, B1 and B2. C Full-field electroretinography (ERG) was normal at 3-month follow-up in the eyes with transplanted photoreceptor precursors. C1, C2 and C3 each represent ERG recordings from 3 different NHPs. The terms DA and LA refer to dark-adapted and light-adapted. The numbers refer to flash strength in cd s m−2

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