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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity

Fig. 4

Decreased CD45/ALDHbr during pulmonary fibrosis. A Lung hydroxyproline content on day 14 in the PBS (n = 4) and the BLM (n = 9) groups. **P < 0.01. B Percentages of ALDHbr, CD45/ALDHbr, CD45/ALDHbr/EpCAM+, and CD45/ALDHbr/PDGFRα+ cells in total lung cells during BLM-induced pulmonary fibrosis (n = 6/group). *P < 0.05, **P < 0.01. ns, not significant. C Correlations between lung hydroxyproline content on day 14 and percentages of ALDHbr, CD45/ALDHbr, CD45/ALDHbr/EpCAM+, and CD45/ALDHbr/PDGFRα+ cells in total lung cells. D Real-time quantitative PCR analysis of the mRNA expression levels of ALDH isoforms in the lungs obtained from the PBS (n = 4) and BLM (n = 9) groups on day 14. Values are expressed relative to the expression of the endogenous control β-actin mRNA. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01

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