Fig. 8
From: Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity
Summary of the study. Lung injury (e.g., bleomycin-induced lung injury) triggers reduction of ALDHbr cells in the lung, resulting in a suppressed retinol-metabolizing pathway, elevated concentrations of profibrotic cytokines (e.g., IL-6 and TGFβ1), and exacerbation of pulmonary fibrosis. Aging accelerates the injury-induced reduction in ALDHbr cells. ALDHbr cell therapy restores the impaired antifibrotic effects of ALDHbr cells. Solid and dotted arrows indicate promotion and inhibition, respectively