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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Targeted gene correction and functional recovery in achondroplasia patient-derived iPSCs

Fig. 3

Chondrogenic differentiation of ACH iPSCs. a A multi-step chondrogenic induction method. b Chondrogenic clusters from ACH iPSCs were less and smaller than those from healthy iPSCs. Bar: 100 μm. c Safranin O staining displayed that there were fewer positive areas and lower cartilage density in cartilage tissues from ACH iPSCs than those from healthy iPSCs. Bar: 10 μm. d RT-qPCR results also exhibited that cartilage tissues derived from ACH iPSCs expressed lower chondrocyte-specific genes, such as SOX9, COL2A1, and ACAN, than those from healthy iPSCs. Symbol “*” stands for p < 0.05. Symbol “**” stands for p < 0.01. Symbol “***” stands for p < 0.001. Symbol “****” stands for p < 0.0001

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