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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Feline adipose-derived mesenchymal stem cells induce effector phenotype and enhance cytolytic function of CD8+ T cells

Fig. 6

ASC-primed CD8+ T cells acquired enhanced cytotoxicity function on target cells. Inverted microscopic images (400X) of A CRFK cells alone in culture B CRFK cells in culture with bead-enriched CD8+ T cells from activated PBMCs after 4 h of incubation C CRFK cells in culture with bead-enriched CD8+ T cells from co-cultures after 4 h of incubation. Black arrow head indicates CRFK cells; white arrow head indicates enriched CD8+ T cells; boxed areas demonstrate loss of monolayer adherence of CRFK cells D Summary of increased LDH activity from lysis of target cells by ASC-primed CD8+ T cells (deducted by spontaneous release of LDH from CRFK cells and enriched CD8+ T cells alone) (n = 5, p-value = 0.04)

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