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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Human Wharton's jelly-derived mesenchymal stem cells alleviate concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis

Fig. 1

hWJ-MSCs effectively protected mouse from Con A-induced fulminant hepatitis. A Schematic illustration of the experimental design. B The survival curves of mice in indicated groups within 120 h after Con A administration. C and D Serum AST (C) and ALT (D) levels were measured at indicated time point after Con A treatment in indicated groups. E Representative gross appearance of livers 24 h after Con A treatment in indicated groups. F Representative H&E staining photographs (left) and quantification of necrosis areas (right, n = 5/group) of liver tissues 24 h after Con A administration in indicated groups. Scale bar = 100 μm. Magnified images of the boxed areas were shown at the bottom. G Live imaging of DiR-labeled MSCs at indicated time point after Con A administration using Xenogen IVIS Lumina II. PBS was used as a negative control. H Imaging of different organs dissected at 24 h after Con A administration in indicated groups using Xenogen IVIS Lumina II. Data in (BD) are shown as mean ± SD (n = 9–12/group) with the indicated significance (*p < 0.05, **p < 0.01, ***p < 0.001)

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